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1

ChemInform Abstract: Subtype-Selective N-Methyl-D-aspartate Receptor Antagonists: Benzimidazolone and Hydantoin as Phenol Replacements.

Robert M. Schelkun, Po-wai Yuen, Kevin Serpa, Leonard T. Meltzer, Lawrence D. Wise, Edward R. Whittemore, Richard M. Woodward

Journal:

Year:

2000

File:

PDF, 32 KB

2000

2

Chemistry and Pharmacology of Nicotinic Ligands Based on 6-[5-(Azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for Possible Use in Depression

Alan P. Kozikowski, J. Brek Eaton, Krishna Mohan Bajjuri, Sheela K. Chellappan, Yihua Chen, Sudhakar Karadi, Rong He, Barbara Caldarone, Michael Manzano, Po-Wai Yuen, Ronald J. Lukas

Journal:

Year:

2009

Language:

english

File:

PDF, 448 KB

english, 2009

3

Heteroaromatic side-chain analogs of pregabalin

Robert M. Schelkun, Po-wai Yuen, David J. Wustrow, Jack Kinsora, Ti-Zhi Su, Mark G. Vartanian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 112 KB

english, 2006

4

A short, stereospecific route to chiral trans-2,6-disubstituted quinuclidines

E.J Corey, Po-wai Yuen

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 230 KB

english, 1989

5

Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant.

Po-wai Yuen, Gerald D. Kanter, Charles P. Taylor, Mark G. Vartanian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 296 KB

english, 1994

6

N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: A novel antagonist at the 1a/2B NMDA receptor subtype

Amir P. Tamiz, Edward R. Whittemore, Robert M. Schelkun, Po-Wai Yuen, Richard M. Woodward, Sui-Xiong Cai, Eckard Weber, John F.W. Keana

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 175 KB

english, 1998

7

Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers

Po-wai Yuen, Robert M. Schelkun, Balazs Szoke, Katalin Tarczy-Hornoch

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 250 KB

english, 1998

8

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

Robert M. Schelkun, Po-wai Yuen, Thomas C. Malone, David M. Rock, Sally Stoehr, Balazs Szoke, Katalin Tarczy-Hornoch

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 248 KB

english, 1999

9

Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin

Charles P. Taylor, Mark G. Vartanian, Yuen Po-Wai, Christopher Bigge, N. Suman-Chauhan, David R. Hill

Journal:

Epilepsy Research

Year:

1993

Language:

english

File:

PDF, 488 KB

english, 1993

10

Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding

Lin, Guang-da, Chattopadhyay, Debasish, Maki, Masatoshi, Wang, Kevin K. W., Carson, Mike, Jin, Lei, Yuen, Po-wai, Takano, Emiko, Hatanaka, Masakazu, DeLucas, Lawrence J.

Journal:

Natural Structural Biology

Year:

1997

File:

PDF, 1.49 MB

1997

11

Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI

Jun-Feng Feng, Ken C. Van, Gene G. Gurkoff, Christina Kopriva, Rafal T. Olszewski, Minsoo Song, Shifeng Sun, Man Xu, Joseph H. Neale, Po-Wai Yuen, David A. Lowe, Jia Zhou, Bruce G. Lyeth

Journal:

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

12

Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile

Zhang, Hankun, Tückmantel, Werner, Eaton, J. Brek, Yuen, Po-wai, Yu, Li-Fang, Bajjuri, Krishna Mohan, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Caldarone, Barbara, Paterson, Neil E., Lowe, Dav

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 744 KB

english, 2012

13

Carbon tetrachloride?dimethyl sulphone?potassium hydroxide?t-butyl alcohol: a convenient new reagent for gem-dichloromethylenation of alkenes

Poon, Chi-Duen, Yuen, Po-Wai, Man, Tim-On, Li, Chun-Sing, Chan, Tze-Lock

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1984

Language:

english

File:

PDF, 475 KB

english, 1984

14

Novel Use of Substituted 1,4-Dihydrobenz[ d ][1,3]oxazin-2-ones in the Synthesis of Important Aminomethyl o -Nitroanilines

Nikam, Sham S., Yuen, Po-Wai, Kornberg, Brian E., Tobias, Brian, Rafferty, Michael F.

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 163 KB

english, 1997

15

Structure−Activity Relationship Study and Drug Profile of N -(4-Fluorophenylsulfonyl)- l -valyl- l -leucinal (SJA6017) as a Potent Calpain Inhibitor

Inoue, Jun, Nakamura, Masayuki, Cui, Ying-She, Sakai, Yusuke, Sakai, Osamu, Hill, Jeanette R., Wang, Kevin K. W., Yuen, Po-Wai

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 51 KB

english, 2003

16

Subtype-Selective N -Methyl- d -aspartate Receptor Antagonists: Benzimidazalone and Hydantoin as Phenol Replacements

Schelkun, Robert M., Yuen, Po-wai, Serpa, Kevin, Meltzer, Leonard T., Wise, Lawrence D., Whittemore, Edward R., Woodward, Richard M.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 179 KB

english, 2000

17

Structure−Activity Relationship of N -(Phenylalkyl)cinnamides as Novel NR2B Subtype-Selective NMDA Receptor Antagonists

Tamiz, Amir P., Cai, Sui Xiong, Zhou, Zhang-Lin, Yuen, Po-Wai, Schelkun, Robert M., Whittemore, Edward R., Weber, Eckard, Woodward, Richard M., Keana, John F. W.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 116 KB

english, 1999

18

The Novel Calpain Inhibitor SJA6017 Improves Functional Outcome after Delayed Administration in a Mouse Model of Diffuse Brain Injury

Kupina, Nancy C., Nath, Rathna, Bernath, Eric E., Inoue, Jun, Mitsuyoshi, Azuma, Yuen, Po-Wai, Wang, Kevin K.W., Hall, Edward D.

Journal:

Journal of Neurotrauma

Year:

2001

Language:

english

File:

PDF, 366 KB

english, 2001

19

Cover Picture: Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase (ChemBioChem 8/2014)

Oh, Angela, Ho, Yen-Ching, Zak, Mark, Liu, Yongbo, Chen, Xukun, Yuen, Po-wai, Zheng, Xiaozhang, Liu, Yichin, Dragovich, Peter S., Wang, Weiru

Journal:

Year:

2014

File:

PDF, 641 KB

2014

20

Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility

Zak, Mark, Liederer, Bianca M., Sampath, Deepak, Yuen, Po-wai, Bair, Kenneth W., Baumeister, Timm, Buckmelter, Alexandre J., Clodfelter, Karl H., Cheng, Eric, Crocker, Lisa, Fu, Bang, Han, Bingsong, L

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 5.03 MB

english, 2015

21

Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

Oh, Angela, Ho, Yen-Ching, Zak, Mark, Liu, Yongbo, Chen, Xukun, Yuen, Po-wai, Zheng, Xiaozhang, Liu, Yichin, Dragovich, Peter S., Wang, Weiru

Journal:

Year:

2014

Language:

english

File:

PDF, 2.06 MB

english, 2014

22

Section Review: Central & Peripheral Nervous Systems: Therapeutic potential of calpain inhibitors in neurodegenerative disorders

Yuen, Po-Wai, KW Wang, Kevin

Journal:

Expert Opinion on Investigational Drugs

Year:

1996

Language:

english

File:

PDF, 1.35 MB

english, 1996

23

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

Volgraf, Matthew, Sellers, Benjamin D., Jiang, Yu, Wu, Guosheng, Ly, Cuong Q., Villemure, Elisia, Pastor, Richard M., Yuen, Po-wai, Lu, Aijun, Luo, Xifeng, Liu, Mingcui, Zhang, Shun, Sun, Liang, Fu, Y

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.05 MB

english, 2016

24

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors

Zak, Mark, Yuen, Po-Wai, Liu, Xiongcai, Patel, Snahel, Sampath, Deepak, Oeh, Jason, Liederer, Bianca M., Wang, Weiru, O'Brien, Thomas, Xiao, Yang, Skelton, Nicholas, Hua, Rongbao, Sodhi, Jasleen, Wang

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 3.53 MB

english, 2016

25

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

NATH, Rathna, RASER, Kadee J, STAFFORD, Daniel, HAJIMOHAMMADREZA, Iradj, POSNER, Avigail, ALLEN, Hamish, TALANIAN, Robert V., YUEN, Po-wai, GILBERTSEN, Richard B., WANG, Kevin K. W.

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 636 KB

english, 1996

26

A GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in vivo Profile

Villemure, Elisia, Volgraf, Matthew, Jiang, Yu, Wu, Guosheng, Ly, Cuong Q., Yuen, Po-wai, Lu, Aijun, Luo, Xifeng, Liu, Mingcui, Zhang, Shun, Lupardus, Patrick J., Wallweber, Heidi J. A., Liederer, Bia

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 541 KB

english, 2016

27

Aminoisoxazoles as potent inhibitors of tryptophan 2,3-dioxygenase 2 (TDO2)

Pei, Zhonghua, Mendonca, Rohan, Gazzard, Lewis, Pastor, Richard, Goon, Leanne, Gustafson, Amy, VanderPorten, Erica C, Hatzivassiliou, Georgia, Dement, Kevin, Cass, Robert, Yuen, Po-wai, Zhang, Yamin,

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 356 KB

english, 2018

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